Experiments are presented showing that visual search for Mueller-Lyer (ML) stimuli is based on complete configurations, rather than component segments. Segments easily detected in isolation were difficult to detect when embedded in a configuration, indicating preemption by low-level groups. This preemption—which caused stimulus components to become inaccessible to rapid search—was an all-or-nothing effect, and so could serve as a powerful test of grouping. It is shown that these effects are unlikely to be due to blurring by simple spatial filters at (...) early visual levels. It is proposed instead that they are due to more sophisticated processes that rapidly bind contour fragments into spatially-extended assemblies. These results support the view that rapid visual search cannot access the primitives formed at the earliest stages of visual processing; rather, it can access only higher-level, more ecologically-relevant structures. (shrink)

Reviews the book, What’s behind the research? Discovering hidden assumptions in the behavioral sciences by Brent D. Slife and Richard N. Williams . As the book's subtitle indicates, the authors' purpose is to assist the reader in Discovering hidden assumptions in the behavioral sciences, a worthy objective not likely to be realized simply through a love affair with "information" and its packaging. Slife and Williams state their mission clearly: "Presenting hidden assumptions, along with their costs and consequences, is our task (...) in this book. Whether you are a student of the behavioral sciences, therapist, educator, businessperson, or simply a consumer of behavioral science information, you will need to know the implicit ideas in that information. What are the main interpretations of the data by scientists? What alternative methods are available for gathering knowledge? What ideas are embedded in the usual approaches to abnormality and treatment? Are there other ideas available for generating solutions to human problems? Do conventional approaches to business or education include assumptions about the world or human nature that are questionable or unacceptable to the people who use them? We attempt to answer these and many other questions." In most respects, Slife and Williams do a splendid job at this. Many of the central conceptual issues Slife and Williams have raised have been treated before 2012 APA, all rights reserved). (shrink)

The eukaryotic genome is packaged into a periodic nucleoprotein structure termed chromatin. The repeating unit of chromatin, the nucleosome, consists of DNA that is wound nearly two times around an octamer of histone proteins. To facilitate DNA‐directed processes in chromatin, it is often necessary to rearrange or to mobilize the nucleosomes. This remodeling of the nucleosomes is achieved by the action of chromatin‐remodeling complexes, which are a family of ATP‐dependent molecular machines. Chromatin‐remodeling factors share a related ATPase subunit and participate (...) in transcriptional regulation, DNA repair, homologous recombination and chromatin assembly. In this review, we provide an overview of chromatin‐remodeling enzymes and discuss two possible mechanisms by which these factors might act to reorganize nucleosome structure. BioEssays 25:1192–1200, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Traducción de Jaime Bermúdez Escamilla sobre Political Aphorisms (1659), en The Oceana and other Works of James Harrington, with an Account of his Life by John Toland, Londres, printed for T. Becket, T. Cadell y T. Evans, 1771, pp. 483-490. Texto inglés consultado en The Online Library of Liberty, Liberty Fund (www.libertyfund.org).

This article reviews models of the cerebellum and motor learning, from the landmark papers by Marr and Albus through those of the present time. The unique architecture of the cerebellar cortex is ideally suited for pattern recognition, but how is pattern recognition incorporated into motor control and learning systems? The present analysis begins with a discussion of exactly what the cerebellar cortex needs to regulate through its anatomically defined projections to premotor networks. Next, we examine various models showing how the (...) microcircuitry in the cerebellar cortex could be used to achieve its regulatory functions. Having thus defined what it is that Purkinje cells in the cerebellar cortex must learn, we then evaluate theories of motor learning. We examine current models of synaptic plasticity, credit assignment, and the generation of training information, indicating how they could function cooperatively to guide the processes of motor learning. (shrink)

In the world of research, compliance with research regulations is not the same as ethics, but it is closely related. One could say that compliance is how most societies with advanced research programs operationalize many ethical obligations. This paper reports on the development of the How I Think about Research questionnaire, which is an adaptation of the How I Think questionnaire that examines the use of cognitive distortions to justify antisocial behaviors. Such an adaptation was justified based on a review (...) of the literature on mechanisms of moral disengagement and self-serving biases, which are used by individuals with normal personalities in a variety of contexts, including research. The HIT-Res adapts all items to refer to matters of research compliance and integrity rather than antisocial behaviors. The HIT-Res was administered as part of a battery of tests to 300 researchers and trainees funded by the US National Institutes of Health. The HIT-Res demonstrated excellent reliability. Construct validity was established by the correlation of the HIT-Res with measures of moral disengagement, cynicism, and professional decision-making in research. The HIT-Res will enrich the set of assessment tools available to instructors in the responsible conduct of research and to researchers who seek to understand the factors that influence research integrity. (shrink)

Features of gait are determined at multiple levels, from the selection of the gait itself (e.g. walk or run) through the specific parameters utilized (stride length, frequency, etc.) to the pattern of muscular excitation. The ultimate choices are neurally determined, but what is involved with that decision process? Human locomotion appears stereotyped not so much because the pattern is predetermined, but because these movement patterns are good solutions for providing movement utilizing the machinery available to the individual (the legs and (...) their requisite components). Under different circumstances the appropriate solution may differ broadly (different gait) or subtly (different parameters). Interpretation of the neural decision making process would benefit from understanding the influences that determine the selection of the appropriate solution in any set of circumstances, including that of normal conditions. In this review we survey an array of studies that point to energetic cost as a key input to the gait coordination system, and not just an outcome of the gait pattern implemented. We then use that information to rigorously define the construct proposed by Sparrow and Newell (1998) where the effects of environment, organism and task act as constraints determining the solution set available, and the coordination pattern is then implemented under a pressure for energetic economy. Environment is defined in terms of affordances based on the ecological psychology definition of the concept and organism is defined as classic morphology and physiology based capabilities. We rely on a novel conceptualization of task that recognizes that the task goal needs to be separated from the mechanisms that achieve the goal if the motivation behind the selection of the mechanism strategy is to be exposed and understood. This reformulation of the Sparrow and Newell construct is then linked to the proposed pressure for economy by considering it as an optimization problem, where the most readily selected gait strategy will be that which achieves the task goal at (or near) the energetic minimum. (shrink)

This paper aims to take the measure of the strand of early modern anti-clericalism that was conveyed by the term “priestcraft”. Priestcraft amounted to the claim that priests had usurped civil power and accumulated material wealth by systematically deceiving the laity and its secular rulers. Religion as it was practised and avowed by believers in early modern Europe was left tainted by this charge since manifold aspects of religious practice and belief fell under the pall of the suspicion that they (...) were merely part of the ruse perpetrated through the centuries by greedy and power-hungry priests. While the English language was particularly effective in condensing this claim into the term in question, mistrust of the clergy informed numerous discourses unfolding in diverse confessional and intellectual contexts. The present article seeks to draw attention to the thematic richness of priestcraft as an object of historical inquiry by identifying the multiple ways in which this trope made its presence felt in the early modern world. (shrink)

A brief review is given of the continuous spontaneous localization (CSL) model, in which a classical field interacts with quantized particles to cause dynamical wavefunction collapse. One of the model's predictions is that particles “spontaneously” gain energy at a slow rate. When applied to the excitation of a nucleon in a Ge nucleus, it is shown how a limit on the relative collapse rates of neutron and proton can be obtained, and a rough estimate is made from data. When applied (...) to the spontaneous excitation of 1s electrons in Ge, by a more detailed analysis of more accurate data than given previously, an updated limit is obtained on the relative collapse rates of the electron and proton, suggesting that the coupling of the field to electrons and nucleons is mass proportional. (shrink)

Numerous accounting and economics research studies employ an experimental research method requiring student participants to make representations about an individual characteristic (e.g., ability, cost) that provides a basis for payment of cash rewards. In response, many participants intentionally misrepresent the nature of that characteristic to receive a greater reward. Typically, such studies are deemed to be either exempt from review by institutional review boards (IRBs) or subject only to an expedited review. Moreover, investigators seldom debrief participants, purportedly to avoid contamination (...) of the participant pool. The authors question the ethics of inducing strategic misrepresentation and rewarding fraudulent behavior without appropriate debriefing. A theoretical framework of cognitive ethical development indicates that such research methods can be harmful to student participants. Furthermore, principles of operant conditioning suggest that the rewards reinforce fraudulent behavior. It is recommended that research studies inducing strategic misrepresentation should not be exempt from IRB review and should be required to include desensitization procedures for debriefing participants. (shrink)

Why does one theory "succeed" while another, possibly clearer interpretation, fails? By exploring two observationally equivalent yet conceptually incompatible views of quantum mechanics, James T. Cushing shows how historical contingency can be crucial to determining a theory's construction and its position among competing views. Since the late 1920s, the theory formulated by Niels Bohr and his colleagues at Copenhagen has been the dominant interpretation of quantum mechanics. Yet an alternative interpretation, rooted in the work of Louis de Broglie in (...) the early 1920s and reformulated and extended by David Bohm in the 1950s, equally well explains the observational data. Through a detailed historical and sociological study of the physicists who developed different theories of quantum mechanics, the debates within and between opposing camps, and the receptions given to each theory, Cushing shows that despite the preeminence of the Copenhagen view, the Bohm interpretation cannot be ignored. Cushing contends that the Copenhagen interpretation became widely accepted not because it is a better explanation of subatomic phenomena than is Bohm's, but because it happened to appear first. Focusing on the philosophical, social, and cultural forces that shaped one of the most important developments in modern physics, this provocative book examines the role that timing can play in the establishment of theory and explanation. (shrink)

From the beginning, the implications of quantum theory for our most general understanding of the world have been a matter of intense debate. Einstein argues that the theory had to be regarded as fundamentally incomplete. Its inability, for example, to predict the exact time of decay of a single radioactive atom had to be due to a failure of the theory and not due to a permanent inability on our part or a fundamental indeterminism in nature itself. In 1964, John (...) Bell derived a theorem which showed that any deterministic theory which preserved locality would have certain consequences for measurements performed at a distance from one another. An experimental check seems to show that these consequences are not, in fact, realized. The correlation between the sets of events is much stronger than any local deterministic theory could allow. What is more, this stronger correlation is precisely that which is predicted by quantum theory. The astonishing result is that local deterministic theories of the classical sort seem to be permanently excluded. Not only can the individual decay not be predicted, but no future theory can ever predict it. The contributors in this volume wrestle with this conclusion. Some welcome it; others leave open a return to at lease some kind of deterministic world, one which must however allow something like action-at-a distance. How much lit it? And how can one avoid violating relativity theory, which excludes action-at-a-distance? How can a clash between the two fundamental theories of modern physics, relativity and quantum theory, be avoided? What are the consequences for the traditional philosophic issue of causality explanation and objectivity? One thing is certain; we can never return to the comfortable Newtonian world where everything that happened was, in principle, predictable and where what happened at one measurement site could not affect another set of measurements being performed light-years away, at a distance that a light-signal could not bridge. Contributors: James T. Cushing, Abner Shimony, N. David Mermin, Jon P. Jarrett, Linda Wessels, Bas C. van Fraassen, Jeremy Butterfield, Michael L. G. Redhead, Henry P. Stapp, Arthur Fine, R. I. G. Hughes, Paul Teller, Don Howard, Henry J. Folse, and Ernan McMullin. (shrink)

Background U.S. federal regulations require that certain ethical elements be followed to protect human research subjects. The location and clinical circumstances of a proposed research study can differ substantially and can have significant implications for these ethical considerations. Both the location and clinical circumstances are particularly relevant for research in intensive care units (ICUs), where patients are often unable to provide informed consent to participate in a proposed research intervention. Purpose Our goal is to elaborate on the updated 2013 U.S. (...) Food and Drug Administration (FDA) guidance document regarding an exemption from the requirement of obtaining informed consent from patients or their surrogates and to address certain elements within that document, thereby assisting clinicians in developing a framework for emergency research in accordance with the regulatory bodies at their own institutions and in the United States. Methods Review of the 2011 and updated FDA guidance document on exemption from informed consent. Results The current process of obtaining informed consent within ICUs needs to be revisited, especially for research in which timely informed consent is not likely. In particular, the process of obtaining informed consent may not be appropriate or even ethical for critically ill patients in extremis who require an intervention for which there is no current acceptable standard of care and clinical equipoise exists. We provide clinicians with a viewpoint that further elaborates on the FDA guidance document. Limitations The viewpoints provided herein are those of the authors and are therefore inherently limited by the personal views of a selected few. Other clinicians or researchers may not interpret the FDA guidelines in a similar manner. Moreover, the discussion of a guideline document is a limitation in and of itself. The guidelines set forth by the FDA are precisely that—guidelines. Therefore, they may not be followed as outlined in the guidance document within one’s own institution. Our goal is that, by elaborating on the guidelines for planned research involving human subjects in the ICU, institutional regulatory bodies may gain a better understanding in drafting their own document when faced with a clinician or a researcher who wishes to conduct planned research in an ICU. Conclusions We believe that the interpretations provided will allow clinicians to safely undertake planned research in ICUs without endangering the main tenets of ethical research involving human participants. This research is needed for the advancement of care in the critically ill. (shrink)

Empirical adequacy, formal explanation and understanding are distinct goals of science. While no a priori criterion for understanding should be laid down, there may be inherent limitations on the way we are able to understand explanations of physical phenomena. I examine several recent contributions to the exercise of fashioning an explanatory discourse to mold the formal explanation provided by quantum mechanics to our modes of understanding. The question is whether we are capable of truly understanding (or comprehending) quantum phenomena, as (...) opposed to simply accepting the formalism and certain irreducible quantum correlations. The central issue is that of understanding versus merely redefining terms to paper over our ignorance. (shrink)

Previous studies of corporate environmental and social action identify exactly three similar patterns of activity. They provide divergent structural explanations for these patterns, as networks of institutional constraint, and networks of local inter-dependence, respectively. A theory of sociocultural viability, known in anthropology and policy science as Cultural Theory, explains that social systems consist of four patterns of social interaction, shaped by two distinct structural factors. Our own analysis of 45 items of environmental, social, and governance factors reconcile extant studies’ findings (...) with Cultural Theory’s expectations. Although earlier studies of corporate social action observed only three patterns of activity, our analysis uncovered the fourth, and that diverging structural explanations of earlier studies are partial and complementary, clarified by Cultural Theory. Our call for further study leverages the normative dimension of Cultural Theory, which specifies policy processes that privilege human decency over parochial preference functions. (shrink)

We are often told that quantum phenomena demand radical revisions of our scientific world view and that no physical theory describing well defined objects, such as particles described by their positions, evolving in a well defined way, let alone deterministically, can account for such phenomena. The great majority of physicists continue to subscribe to this view, despite the fact that just such a deterministic theory, accounting for all of the phe nomena of nonrelativistic quantum mechanics, was proposed by David Bohm (...) more than four decades ago and has arguably been around almost since the inception of quantum mechanics itself. Our purpose in asking colleagues to write the essays for this volume has not been to produce a Festschrift in honor of David Bohm or to gather together a collection of papers simply stating uncritically Bohm's views on quantum mechanics. The central theme around which the essays in this volume are arranged is David Bohm's version of quantum mechanics. It has by now become fairly standard practice to refer to his theory as Bohmian mechanics and to the larger conceptual framework within which this is located as the causal quantum theory program. While it is true that one can have reservations about the appropriateness of these specific labels, both do elicit distinc tive images characteristic of the key concepts of these approaches and such terminology does serve effectively to contrast this class of theories with more standard formulations of quantum theory. (shrink)

One of the major philosophical problems in physical sciences is what criteria should determine how scientific theories are selected and justified in practice and whether, in describing observable physical phenomena, such theories are effectively constrained to be unique. This book studies the example of a particular theory, the S-matrix theory. The S-matrix program was initiated by Heisenberg to deal with difficulties encountered in quantum field theories in describing particular phenomena. Since then, each theory has at different times been favored as (...) the explanation of observed phenomena. Certainly the S-matrix theory was adequate, feasible and fertile. However, the quantum field theory interpretation is now widely accepted and the study of alternative theories is all but abandoned. By examining the philosophy which influenced the turns in this story, the author explains how an adequate and viable theory fell out of favor and concludes with a critique of different methodologies in the history of science. (shrink)

This paper is a critique of a project, outlined by Laudan et al. (1986) recently in this journal, for empirically testing philosophical models of change in science by comparing them against the historical record of actual scientific practice. While the basic idea of testing such models of change in the arena of science is itself an appealing one, serious questions can be raised about the suitability of seeking confirmation or disconfirmation for large numbers of specific theses drawn from a massive (...) list of claims abstracted from the writings of a few philosophers of science. The present paper discusses what one might reasonably expect from a model of change in science and then compares some clusters of theses from Laudan et al. with developments in recent theoretical physics. The results suggest that such straightforward testing of theses may be largely inconclusive. (shrink)

Any division between scientific practice and a metalevel of the methods and goals of science is largely a false dichotomy. Since a priori, foundationist or logicist approaches to normative principles have proven unequal to the task of representing actual scientific practice, methodologies of science must be abstracted from episodes in the history of science. Of course, it is possible that such characteristics could prove universal and constant across various eras. But, case studies show that they are not in anything beyond (...) the strictures applied to everyday, commonsense reasoning (e.g., a requirement of noncontradiction in a deductive argument). Hence, even if some presently-on-offer methodology or description of past scientific practice were adequate, it need not remain so for current (‘frontier’) areas of science. For this reason, it is important to examine recent episodes in, say, high-energy physics. Results from case studies of several episodes in that field are used to argue that successful practice leads scientists to countenance essential changes in the methodological framework at the levels of the criteria employed in judging theories (i.e., what counts for an explanation and what are canons of rationality) and of the goals of science. *Partial support for this research was provided by the History and Philosophy of Science Program of the National Science Foundation under grants Nos. SES-8606472 and SES-8705469. A preliminary version of this paper was given at an HPS seminar at King's College, London University in May 1988. Helpful comments and useful criticisms were made by several colleagues, especially Ernan McMullin, Heinz Post and Simon Saunders (none of whom are to be held responsible for or necessarily even in agreement with the views expressed here.). (shrink)

A case study of the development of quantum field theory and of S-matrix theory, from their inceptions to the present, is presented. The descriptions of science given by Kuhn and by Lakatos are compared and contrasted as they apply to this case study. The episodes of the developments of these theories are then considered as candidates for competing research programs in Lakatos' methodology of scientific research programs. Lakatos' scheme provides a reasonable overall description and a plausible assessment of the relative (...) value of these two programs in terms of progressive and degenerating problem shifts. Also discussed are the roles of various types of models as they have been used in these areas of theoretical high-energy physics. (shrink)

This article investigates the key aspects of the Confucian virtue ethics such as the "chun- tzu" (Superior Person), the Five Relationships of society, the particular Confucian virtues of "jen" (benevolence) and "li" (propriety), the moral vision of the "tao" (Way), and the understanding of the "t'ien- ming" (Mandate of Heaven). The thesis of the article is that the moral matrix provided by the web of social relationships allows the Confucian ethics of virtue to function well, and that a consideration of (...) this Confucian moral matrix may illuminate the Western debate on the ethics of virtue vs the ethics of duty. (shrink)

In the recent philosophy of science literature, several authors have stressed the many-faceted and evolving nature of the scientific enterprise. Dudley Shapere (1984, pp. xiii-xv) characterizes a central weakness of the logical empirical program as its focus on the formal logical structure of scientific theories to the exclusion of the process by which these theories were constructed, thus ignoring the possibility of fundamental changes in the nature of science itself. He has stressed the importance of formulating a view of science (...) based on an accurate description of actual scientific practice, which includes attention to how the meaning of a scientific term is rooted in this evolving matrix of practice. Janet Kourany (1982) has attempted” …to lay the foundations for a purely empirical method for establishing a theory of science” (p. 526). In arguing that the a priori has no place in such an approach and in responding to the charge that such an empirical method cannot produce an absolutely fixed set of criteria, Kourany (p. 546) reminds us of Popper’s observation about another empirical enterprise and suggests that we apply this same admonition to our expectations for an empirical method of constructing a theory of science itself. (shrink)

In the philosophy of science, we are to assess critically and on their intrinsic merits various proposals for a consistent interpretation of quantum mechanics, including resolutions of the measurement problem and accounts of the long-range Bell correlations. In this paper I suggest that the terms of debate may have been so severely and unduly constrained by the reigning orthodoxy that we labor unproductively with an unhelpful vocabulary and set of definitions and distinctions. I present an alternative conceptual framework, free of (...) many of the standard conundrums. (shrink)

The ubiquity of chaos in classical mechanics (CM), as opposed to the situation in standard quantum mechanics (QM), might be taken as speaking against QM being the fundamental theory of physical phenomena. Bohmian mechanics (BM), as a formulation of quantum theory, may clarify both the existence of chaos in the quantum domain and the nature of the classical limit. Two interesting possibilities are (i) that CM and classical chaos are included in and underwritten by quantum mechanics (BM) or (ii) that (...) BM and CM simply possess a common region of (noninclusive) overlap. In the latter case, neither CM nor QM alone would be sufficient, even in principle, to account for all of the physical phenomena we encounter. In this talk I shall summarize and discuss the implications of some recent work on chaos and on the classical limit within the framework of BM. (shrink)

I argue that historical contingency, in the sense of the order in which events take place, can be an essential factor in determining which of two equally adequate and fruitful, but observationally indistinguishable, scientific theories is accepted by the scientific community. This type of actual underdetermination poses questions for scientific realism and for rational reconstruction in theory evaluation. To illustrate this, I discuss the complete observational equivalence of two radically different, conceptually incompatible interpretations of quantum mechanics and argue that an (...) entirely plausible reordering of historical factors could reasonably have resulted in the causal program having been chosen over the "Copenhagen" one. (shrink)

An exploration of the moral and ethical implications of new biotechnologies Many of the ethical issues raised by new technologies have not been widely examined, discussed, or indeed settled. For example, robotics technology challenges the notion of personhood. Should a robot, capable of making what humans would call ethical decisions, be held responsible for those decisions and the resultant actions? Should society reward and punish robots in the same way that it does humans? Likewise, issues of safety, environmental concerns, and (...) distributive justice arise with the increasing acceptance of genetically modified organisms in food production nanotechnology in engineering and medicine, and human gene therapy and enhancement. The problem of dual-use—when a technology can be used both to benefit and to harm—exists with virtually all new technologies but is central in the context of emerging 21st century technologies ranging from artificial intelligence and robotics to human gene-editing and brain-computer interfacing. In Re-Creating Nature: Science, Technology, and Human Values in the Twenty-First Century, James T. Bradley addresses emerging biotechnologies with prodigious potential to benefit humankind but that are also fraught with ethical consequences. Some actually possess the power to directly alter the evolution of life on earth including human. Specifically, these topics include stem cells, synthetic biology, GMOs in agriculture, nanotechnology, bioterrorism, CRISPR gene-editing technology, three-parent babies, robotics and roboethics, artificial intelligence, and human brain research and neurotechnologies. Offering clear explanations of these various technologies, a pragmatic presentation of the conundrums involved, and questions that illuminate hypothetical situations, Bradley guides discussions of these and other thorny issues resulting from the development of new biotechnologies. He also highlights the responsibilities of scientists to conduct research in an ethical manner and the responsibilities of nonscientists to become “science literate” in the twenty-first century. (shrink)

In his book Radical Evolution: The Promise and Peril of Enhancing Our Minds, Our Bodies—and What It Means to Be Human (2005), author-journalist Joel Garreau identifies four technologies whose synergistic activity may transform humankind into a state transcending present human nature: genetic, robotic, information, and nano (GRIN) technologies. If the GRIN technologies follow Moore's Law, as information technology has done for the past four decades, Homo sapiens and human society may be unimaginably different before the middle of this century. But (...) among scientists, futurists, and other pundits there is no agreement on the nature and ramifications of this transformation. Based on dozens of interviews, Garreau sees three possible scenarios for our species. The Heaven Scenario foresees enhanced bodies and minds in a disease-free world, perhaps even immortality; the Hell Scenario warns of losing our identity as a biological entity and perhaps the demise of liberal democracy; the Prevail Scenario predicts that we will muddle through the GRIN technology revolution basically intact, as we have prevailed during past technological upheavals. In this review, these scenarios are examined in the context of Kuhn's “normal” versus “extraordinary” science and in the context of current understanding about gene function. (shrink)

It has generally been assumed that rapid visual search is based on simple features and that spatial relations between features are irrelevant for this task. Seven experiments involving search for line drawings contradict this assumption; a major determinant of search is the presence of line junctions. Arrow- and Y-junctions were detected rapidly in isolation and when they were embedded in drawings of rectangular polyhedra. Search for T-junctions was considerably slower. Drawings containing T-junctions often gave rise to very slow search even (...) when distinguishing arrow- or Y-junctions were present. This sensitivity to line relations suggests that preattentive processes can extract 3-dimensional orientation from line drawings. A computational model is outlined for how this may be accomplished in early human vision. (shrink)

Serious ethical violations in medicine, such as sexual abuse, criminal prescribing of opioids, and unnecessary surgeries, directly harm patients and undermine trust in the profession of medicine. We review the literature on violations in medicine and present an analysis of 280 cases. Nearly all cases involved repeated instances of intentional wrongdoing, by males in nonacademic medical settings, with oversight problems and a selfish motive such as financial gain or sex. More than half of cases involved a wrongdoer with a suspected (...) personality disorder or substance use disorder. Despite clear patterns, no factors provide readily observable red flags, making prevention difficult. Early identification and intervention in cases requires significant policy shifts that prioritize the safety of patients over physician interests in privacy, fair processes, and proportionate disciplinary actions. We explore a series of 10 questions regarding policy, oversight, discipline, and education options. Satisfactory answers to these questions will require input from diverse stakeholders to help society negotiate effective and ethically balanced solutions. (shrink)

American intellectual history in the future will be embodied, embedded, and extended. Building on a sturdy foundation of past practices, intellectual historians will consolidate the advances of the last half-century and continue to study ideas articulated in multiple registers, by multiple historical actors, for multiple purposes.

Darwin and the Art of Science will consist of excerpts from six of Darwin's books, chosen and introduced by James Costa. The excerpts will be arranged by plant (rather than according to which book they're from) in order to make the most of extraordinary images provided by the Oak Springs Garden Foundation library. As a group, they will provide unparalleled access to Darwin's fascinating observations and musings about the world of plants and how their distinctive features have evolved.

In this review, we describe some of the central philosophical issues facing origins-of-life research and provide a targeted history of the developments that have led to the multidisciplinary field of origins-of-life studies. We outline these issues and developments to guide researchers and students from all fields. With respect to philosophy, we provide brief summaries of debates with respect to (1) definitions (or theories) of life, what life is and how research should be conducted in the absence of an accepted theory (...) of life, (2) the distinctions between synthetic, historical, and universal projects in origins-of-life studies, issues with strategies for inferring the origins of life, such as (3) the nature of the first living entities (the “bottom up” approach) and (4) how to infer the nature of the last universal common ancestor (the “top down” approach), and (5) the status of origins of life as a science. Each of these debates influences the others. Although there are clusters of researchers that agree on some answers to these issues, each of these debates is still open. With respect to history, we outline several independent paths that have led to some of the approaches now prevalent in origins-of-life studies. These include one path from early views of life through the scientific revolutions brought about by Linnaeus (von Linn.), Wöhler, Miller, and others. In this approach, new theories, tools, and evidence guide new thoughts about the nature of life and its origin.We also describe another family of paths motivated by a” circularity” approach to life, which is guided by such thinkers as Maturana & Varela, Gánti, Rosen, and others. These views echo ideas developed by Kant and Aristotle, though they do so using modern science in ways that produce exciting avenues of investigation. By exploring the history of these ideas, we can see how many of the issues that currently interest us have been guided by the contexts in which the ideas were developed. The disciplinary backgrounds of each of these scholars has influenced the questions they sought to answer, the experiments they envisioned, and the kinds of data they collected. We conclude by encouraging scientists and scholars in the humanities and social sciences to explore ways in which they can interact to provide a deeper understanding of the conceptual assumptions, structure, and history of origins-of-life research. This may be useful to help frame future research agendas and bring awareness to the multifaceted issues facing this challenging scientific question. (shrink)

Intellectual history and the history of political thought are siblings, perhaps even twins. They have similar origins and use similar materials. They attract many of the same friends and make some of the same enemies. Yet like most siblings, they have different temperaments and ambitions. This essay explores the family resemblances and draws out the contrasts by examining two major works by one of the most prominent political theorists of the past half-century, Alan Ryan, who has recently published two big (...) books that intellectual historians will find rewarding and provocative. (shrink)

This paper provides a statistical survey of the incidence of elision at the penthemimeral caesura in the iambic trimeters of Greek tragedy. It updates and builds on the work of Descroix by considering the rates of elision of different types of words: lexicals, nonlexical polysyllables, and nonlexical monosyllables. While all tragedians elide less at the caesura than throughout the line, in Aeschylus the rate of this reduction is far greater for lexicals and polysyllabic nonlexicals than it is for monosyllabic nonlexicals. (...) On this evidence, and the evidence of interlinear elision, it is tentatively suggested that lexicals and nonlexical polysyllables should together be considered as the more constrained elisions. When the rates of constrained elision are examined, the difference between Aeschylus and later Euripides is revealed to be twice that obtained when bulk figures are used. This difference is attributed to a combination of Euripides’ adoption of more fluent phrasing towards the end of his career and the tragedians’ different approaches to compositional constraints. (shrink)

It was the lack of hope for political reform that turned a neo-Confucianist school led by chu hsi to develop comprehensive metaphysical principles and integrated social actions as the only true way to put the confucian value system into practice. An ill-Advised persecution led to the contrary result: a heightened prestige. Facing the mongol threat, The state in an effort to strengthen itself belatedly adopted this school as the state orthodoxy, More for prestige than for reality. When the mongols occupied (...) all china, It was to this neo-Confucianism that the chinese society turned for its cultural identity. This was the socio-Political process by which a re-Defined confucian value system came to pervade china, Even among the illiterate. (shrink)